B-cells can contribute to immunity by producing antibodies, by antigen presentation on T-cells and by cytokine production. We recently found that plasma cells are the major part of interleukin-10 secreting B cells during bacterial infection. This finding might indicate that antibody-secreting cells (ASC) contribute to immunity by secreting cytokines. The aim of this project is to comprehensively investigate the antibody-independent functions of ASCs in autoimmune diseases.
Deutsches Rheuma-Forschungszentrum Berlin (DRFZ)
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E-Mail: fillatreau @ drfz.de